Square pyramidal copper(II) complexes with forth generation fluoroquinolone and neutral bidentate ligand: Structure, antibacterial, SOD mimic and DNA-interaction studies

Coordination of neutral bidentate ligand to copper ion in combination with gatifloxacin have been focused in this article. The effect of complexation reflects antibacterial activity, DNA interaction and SOD mimic activity of individual greatly. The geometry at the central metal ion provides a site for binding of superoxide anion responsible for better SOD mimic behaviour.

Formulation of copper complexes using drug and some NN/NO donor ligands resulting in efficiency compounds that can act as DNA gyrase and exhibit SOD resemblance.Figure optionsDownload as PowerPoint slide