کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356430 | 981116 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors](/preview/png/1356430.png)
چکیده انگلیسی
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 3, 1 February 2010, Pages 1273–1279
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 3, 1 February 2010, Pages 1273–1279
نویسندگان
Franco Chimenti, Rossella Fioravanti, Adriana Bolasco, Paola Chimenti, Daniela Secci, Francesca Rossi, Matilde Yáñez, Francisco Orallo, Francesco Ortuso, Stefano Alcaro, Roberto Cirilli, Rosella Ferretti, M. Luisa Sanna,