کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1356633 | 981138 | 2008 | 7 صفحه PDF | دانلود رایگان |
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.
Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of protein tyrosine phosphatase 1B(PTP1B) in an in vitro assay with IC50 values ranging from 13.9 ± 2.1 to 19.0 ± 1.8 μM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 24, 15 December 2008, Pages 10356–10362