کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1356754 981151 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of 3′-deoxy-3′-C-methyl nucleoside derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of 3′-deoxy-3′-C-methyl nucleoside derivatives
چکیده انگلیسی
2′,3′-Dideoxy-3′-C-methyl nucleosides bearing the five naturally occurring nucleic acid bases were synthesized. Additionally, the 3′-deoxy-3′-C-methyl nucleoside analogues bearing 5-aminoimidazole-4-carboxamide as well as 1,2,4-triazole-3-carboxamide moieties were prepared. The synthesis of the corresponding 2′,3′-dideoxy-3′-C-methyl triazole derivative was also accomplished. The dideoxynucleoside derivatives were prepared by radical deoxygenation from their 3′-deoxy-3′-C-methyl parent ribonucleosides. When evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 15, 1 August 2008, Pages 7436-7442
نویسندگان
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