Trypanocidal activity of a new pterocarpan and other secondary metabolites of plants from Northeastern Brazil flora

Two hundred fifteen compounds isolated from plants of Northeastern Brazil flora have been assayed against epimastigote forms of Trypanosoma cruzi, using the tetrazolium salt MTT as an alternative method. Eight compounds belonging to four different species: Harpalyce brasiliana (Fabaceae), Acnistus arborescens and Physalis angulata (Solanaceae), and Cordia globosa (Boraginaceae) showed significant activity. Among them, a novel and a known pterocarpan, a chalcone, four withasteroids, and a meroterpene benzoquinone were the represented chemical classes.

This novel pterocarpan showed activity in vitro against epimastigote forms of Trypanosoma cruzi using the tetrazolium salt MTT as an alternative method.Figure optionsDownload as PowerPoint slide