کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1356790 981159 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Orally active 1,2,4-trioxepanes: Synthesis and antimalarial activity of a series of 7-arylvinyl-1,2,4-trioxepanes against multidrug-resistant Plasmodium yoelii in Swiss mice
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Orally active 1,2,4-trioxepanes: Synthesis and antimalarial activity of a series of 7-arylvinyl-1,2,4-trioxepanes against multidrug-resistant Plasmodium yoelii in Swiss mice
چکیده انگلیسی

7-Arylvinyl-1,2,4-trioxepanes 7a–d, 8a–d, 9a–d, 10a–d, 11a–c, and 12a–c, prepared by photooxygenation of homoallylic alcohols 5a–d, were evaluated against multi-drug resistant Plasmodium yoelii nigeriensis in Swiss mice by oral and intramuscular routes. Trioxepane 11c, the most active compound of the series, showed more than 98% suppression of parsitaemia at 96 mg/kg by both oral and intramuscular routes. This is the first report on in vivo active 1,2,4-trioxepanes.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 16, Issue 4, 15 February 2008, Pages 1816–1821
نویسندگان
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