Multicomponent reactions in fungicide research: The discovery of mandipropamid

Isocyanide-based multicomponent reactions of the Ugi- and Passerini-type have been valuable tools for the rapid exploration of the novel fungicidal compound classes of phenylglycinamides and mandelamides. Mandipropamid (6), which was discovered during this derivatisation, displays excellent activity against the economically important phytopathogens Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew).

Mandipropamid is a highly efficient new fungicide against the agronomically important oomycetes diseases Phytophthora infestans (potato and tomato late blight) and Plasmopara viticola (grape downy mildew).Figure optionsDownload as PowerPoint slide