کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356881 | 981168 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stereoselective synthesis of β-1-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols and evaluation as UDP-galactopyranose mutase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Stereoselective synthesis of β-1-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols and evaluation as UDP-galactopyranose mutase inhibitors Stereoselective synthesis of β-1-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols and evaluation as UDP-galactopyranose mutase inhibitors](/preview/png/1356881.png)
چکیده انگلیسی
The synthesis of 1-C-substituted 1,4-dideoxy-1,4-imino-d-galactitols involving nitrone umpolung is described. The SmI2-induced key coupling proved highly stereoselective in favor of the β-C-substituted products bearing a three-carbon chain at the pseudoanomeric position. Pyrrolidines 9 and 10, as well as the bicyclic compounds 8 and 11, exhibit weak inhibition of the activity of the UDP-galactopyranose mutase from Escherichia coli.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 19, 1 October 2007, Pages 6443–6449
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 19, 1 October 2007, Pages 6443–6449
نویسندگان
Stéphanie Desvergnes, Valérie Desvergnes, Olivier R. Martin, Kenji Itoh, Hung-wen Liu, Sandrine Py,