کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1356944 | 981177 | 2007 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species. The mode of binding was investigated, and the effect on the plasma glucose level was evaluated. Structure–activity relationships are also presented.
A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and identified as long-acting DPP-IV inhibitors. The mode of binding and the effect on the plasma glucose level were evaluated.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 7, 1 April 2007, Pages 2631–2650
Journal: Bioorganic & Medicinal Chemistry - Volume 15, Issue 7, 1 April 2007, Pages 2631–2650
نویسندگان
Takashi Kondo, Takahiro Nekado, Isamu Sugimoto, Kenya Ochi, Shigeyuki Takai, Atsushi Kinoshita, Yohei Tajima, Susumu Yamamoto, Kazuhito Kawabata, Hisao Nakai, Masaaki Toda,