کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1357001 981184 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Substituent activity relationship studies on new azolo benzoxazepinyl oxazolidinones
چکیده انگلیسی

In an effort to discover potent antibacterials based on the entropically favored ‘bioactive conformation’ approach, a series of novel tricyclic molecules mimicking the conformationally constrained structure of Linezolid is reported. Based on the initial tricyclic molecule 1, the benzazepine derivative 2 was designed where the tricyclic structure had more flexibility around C–N bond compared to 1. While, the molecule 2 was less active, the molecule 3 showed promising antibacterial activity presumably after having obtained rigidity due to pyrrole ring. The syntheses, SAR studies, and evaluation of 3 as a lead compound are reported.

The synthesis of a series of tricyclic oxazolidinones is disclosed. SAR studies on these novel compounds and evaluation of a lead compound are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 23, 1 December 2006, Pages 8032–8042
نویسندگان
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