کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1357033 | 981189 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity](/preview/png/1357033.png)
چکیده انگلیسی
The effect of introducing fluorine atoms or trifluoromethyl groups in either the peptidic chain or the C-terminal end of cationic pentapeptides is reported. Three series of amide and ester peptides were synthesised and their antimicrobial properties evaluated. An enhanced activity was found in those derivatives whose structure contained fluorine, suggesting an increase in their hydrophobicity.
The effect of introducing fluorine atoms or trifluoromethyl groups in cationic pentapeptides is reported. An enhanced antimicrobial activity was found suggesting an increase in their hydrophobicity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 20, 15 October 2006, Pages 6971–6978
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 20, 15 October 2006, Pages 6971–6978
نویسندگان
Diana Giménez, Cecilia Andreu, Marcel·lí del Olmo, Teresa Varea, Dolores Diaz, Gregorio Asensio,