Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test

The present study describes the chemical synthesis and pharmacological evaluation of a new series of eleven compounds stereoisomers of imidobenzenesulfonylaziridines in the forced-swimming test (FST) in mice. The pharmacological results of these compounds show that six of them, given intraperitoneally, reduced the immobility time of mice evaluated in the FST, an antidepressant-like profile of action similar to imipramine, a well-known standard antidepressant drug used for comparison, without compromising the animals’ motor performance. The putative antidepressant-like action demonstrated here indicates their viability for the development of new therapeutic options for the treatment of depression.

X = H (a); 4-Cl (b); 3,4-Cl2 (c); 4-CH3 (d); 4-OCH3 (e); 4-Br (f); 4-NO2 (g); 3-ethyl (h); 3-NO2 (i); 4-F (j) and 4-OH (k).Figure optionsDownload as PowerPoint slide