Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N′-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim

Some N-arylsulfonyl-N-methyl-N′-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas were prepared and evaluated as putative potassium channel openers on the vascular and uterine smooth muscle tissue (myorelaxant effect), as well as on insulin-secreting pancreatic islets (inhibition of insulin release). The pharmacological results indicated that these compounds exhibited a marked biological activity on these three tissues.

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