Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa

The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5–18, four novel alkaloids of this class, compounds 1–4, have been isolated, and their structures established through spectroscopic methods. Compounds 1–4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.

Four novel bromopyrrole alkaloids (compounds 1–4) have been isolated from the sponge Axinella verrucosa and their structures established through spectroscopic methods. Compounds 1–4 exhibited a neuroprotective effect in vitro against the agonists serotonin and glutamate.Figure optionsDownload as PowerPoint slide