کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1357136 | 981205 | 2006 | 5 صفحه PDF | دانلود رایگان |

To aid in the clinical evaluation of zebularine, a potential oral antitumor agent, we initiated studies on the metabolism of zebularine in liver cytosol from humans and other mammals. Metabolism by aldehyde oxidase (AO, EC 1.2.3.1) was the major catabolic route, yielding uridine as the primary metabolite, which was metabolized further to uracil by uridine phosphorylase. The inhibition of zebularine metabolism was studied using raloxifene, a known potent inhibitor of AO, and 5-benzylacyclouridine (BAU), a previously undescribed inhibitor of AO. The Michaelis–Menten kinetics of aldehyde oxidase and its inhibition by raloxifene and BAU were highly variable between species.
Activity and inhibition of aldehyde oxidase on the metabolism of zebularine varied between species. Inhibitors: raloxifene and 5-benzylacyclouridine.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 14, Issue 1, 1 January 2006, Pages 62–66