Heteroarylisopropylamines as MAO inhibitors

The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.

Eleven heteroarylisopropylamines were prepared and evaluated in vitro as MAO-A and MAO-B inhibitors. Molecular dynamics simulation was performed with the most active member of the series, the 1-(2-benzofuryl)-2-aminopropane.Figure optionsDownload as PowerPoint slide