کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1357178 981209 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Steroid-derived phospholipid scramblases induce exposure of phosphatidylserine on the surface of red blood cells
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Steroid-derived phospholipid scramblases induce exposure of phosphatidylserine on the surface of red blood cells
چکیده انگلیسی

A series of methyl 7α,12α-bis(phenylurea) cholate derivatives with different cationic substituents at the 3α-position were prepared and evaluated for an ability to increase the level of endogenous phosphatidylserine (PS) on the surface of red blood cells (erythrocytes). Some of the compounds induced large fractions of erythrocytes to expose sufficient PS to become stained by the protein annexin V-FITC. In addition, the compounds were found to bind PS in homogeneous solution, and to promote the translocation of fluorescent NBD-labeled phospholipids across vesicle membranes, which supports the hypothesis that cholate-induced exposure of endogenous PS on the erythrocyte surface is due to the ability of the cationic cholates to promote anionic phospholipid flip-flop.

A series of methyl 7α,12α-bis(phenylurea) cholate derivatives with different cationic substituents at the 3α-position are evaluated for an ability to increase the level of endogenous phosphatidylserine (PS) on the surface of red blood cells (erythrocytes) and to promote the translocation of fluorescent NBD-labeled phospholipids across vesicle membranes.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 14, 15 July 2005, Pages 4485–4490
نویسندگان
, , ,