کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1357200 981212 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
چکیده انگلیسی

A series of lobelane analogues has been synthesized and their structure–activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with Ki values ranging from 430 to 580 nM.

A series of lobelane analogues has been synthesized and their structure–activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with Ki values ranging from 430 to 580 nM.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 12, 2 June 2005, Pages 3899–3909
نویسندگان
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