کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1357204 | 981212 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of bis-quindolines as new antiinfective agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of bis-quindolines as new antiinfective agents Identification of bis-quindolines as new antiinfective agents](/preview/png/1357204.png)
چکیده انگلیسی
Several N-substituted quindolines were made to further evaluate the role of N-alkylation on the activity of indoloquinolines as antifungal agents. While N-5 substitution is required for these activities, N-10 alkylation alone leads to inactive products but is tolerated in the presence of N-5 alkyl groups. It was also discovered that bis-quindolines appear to have a more expanded antimicrobial spectrum and lower cytotoxicity than their monomeric counterparts.
Novel bis-quindolines with alkylated positively charged N-atoms constitute novel agents with expanded antimicrobial/antiparasitic spectra and lower cytotoxicity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 12, 2 June 2005, Pages 3955–3963
Journal: Bioorganic & Medicinal Chemistry - Volume 13, Issue 12, 2 June 2005, Pages 3955–3963
نویسندگان
Leroy G. Mardenborough, Xue Y. Zhu, Pincheng Fan, Melissa R. Jacob, Shabana I. Khan, Larry A. Walker, Seth Y. Ablordeppey,