Identification of bis-quindolines as new antiinfective agents

Several N-substituted quindolines were made to further evaluate the role of N-alkylation on the activity of indoloquinolines as antifungal agents. While N-5 substitution is required for these activities, N-10 alkylation alone leads to inactive products but is tolerated in the presence of N-5 alkyl groups. It was also discovered that bis-quindolines appear to have a more expanded antimicrobial spectrum and lower cytotoxicity than their monomeric counterparts.

Novel bis-quindolines with alkylated positively charged N-atoms constitute novel agents with expanded antimicrobial/antiparasitic spectra and lower cytotoxicity.Figure optionsDownload as PowerPoint slide