کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1357736 | 981275 | 2015 | 11 صفحه PDF | دانلود رایگان |
A library of 64 benzotriazole derivatives (17 of which were [4-(benzotriazol-2-yl)phenoxy]alkanoic acids) were screened for antiviral activity against a panel of twelve DNA and RNA viruses. Twenty-six compounds (12 of which were [4-(benzotriazol-2-yl)phenoxy]alkanoic acids) displayed activity against one or more viruses. CVB-5, RSV, BVDV, Sb-1 and YFV were, in decreasing order, the more frequently and effectively affected viruses; DENV-2, WNV, HIV-1 and Reo-1 were only occasionally and modestly affected, while the remaining viruses were not affected by any of the tested compounds. Worth of note were compounds 33 and 35; the former for the activity against Sb-1 (EC50 = 7 μM) and the latter for the large spectrum of activity including six viruses with a mean EC50 = 12 μM. Even more interesting were the alkanoic acids 45–48 and 50–57 for their activity against RSV and/or CVB-5. In particular, compound 56 displayed a potent and selective activity against CVB-5 with EC50 = 0.15 μM and SI = 100, thus representing a valuable hit compound for the development of antiviral agents for the treatment of human pathologies related to this virus.
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Journal: Bioorganic & Medicinal Chemistry - Volume 23, Issue 21, 1 November 2015, Pages 7024–7034