Structural elucidation and synthesis of vialinin C, a new inhibitor of TNF-α production

A new inhibitor of TNF-α production (IC50 = 0.89 μM) named vialinin C (1) was isolated from dry fruiting bodies of an edible Chinese mushroom, Thelephora vialis. The structure of 1 was determined by high-resolution MS, NMR spectroscopic analysis, and confirmed by synthesis. Synthesis of ganbajunin B (5) obtained from the same origin was also described.

Figure optionsDownload as PowerPoint slide