کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1357858 | 981300 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of prime-site sequence of retro-inverso-modified HTLV-1 protease inhibitor
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of prime-site sequence of retro-inverso-modified HTLV-1 protease inhibitor Effect of prime-site sequence of retro-inverso-modified HTLV-1 protease inhibitor](/preview/png/1357858.png)
چکیده انگلیسی
The effects of additional substituents covering the prime-site of retro-inverso (RI)-modified HTLV-1 protease inhibitors containing a hydroxyethylamine isoster were clarified. Stereo-selective construction of the most potent isoster backbone was achieved by the Evans-aldol reaction. Addition of N-acetylated d-amino acid corresponding to the P2′ site gave an RI-modified inhibitor showing superior inhibitory activity to the previous inhibitor. Inhibitory activities of the newly synthesized inhibitors suggest that partially modified RI inhibitors would interact with HTLV-1 protease in the same manner as the parent hydroxyethylamine inhibitor.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 8, 15 April 2014, Pages 2482–2488
Journal: Bioorganic & Medicinal Chemistry - Volume 22, Issue 8, 15 April 2014, Pages 2482–2488
نویسندگان
Chiyuki Awahara, Tadashi Tatsumi, Saki Furuta, Gen Shinjoh, Hiroyuki Konno, Kazuto Nosaka, Kazuya Kobayashi, Yasunao Hattori, Kenichi Akaji,