کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1358366 981339 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modified silaffin R5 peptides enable encapsulation and release of cargo molecules from biomimetic silica particles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Modified silaffin R5 peptides enable encapsulation and release of cargo molecules from biomimetic silica particles
چکیده انگلیسی

Biomimetic silica formation has attracted increasing interest over the last decade for numerous biotechnological applications due to the favorable mild reaction conditions. Inspired from silica biogenesis in diatoms, peptide variants derived from native silaffins have been used for silica formation in vitro. Here a generally applicable route for covalently linking a cargo molecule to the R5 silaffin peptide via a disulfide linkage is established. The peptide CG12AB, a peptide ligand of the epidermal growth factor receptor, was chosen as model. The ability of such silaffin-cargo conjugates to encapsulate the cargo molecule during silaffin-mediated silica precipitation is demonstrated. Cargo release from silica material under different conditions was analyzed. The results obtained here provide a rational basis for developing engineered R5 silaffin peptides into efficient tools for silica precipitation as well as for entrapment and release of cargo molecules under physiological conditions.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 12, 15 June 2013, Pages 3533–3541
نویسندگان
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