Beta-carboline alkaloids derived from the ascidian Synoicum sp.

Six β-carboline alkaloids (1–6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y1 (7) and six new derivatives, designated eudistomins Y8–Y13 (8–13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na+/K+−ATPase. Structure–activity relationships were also deduced.

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