کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1358603 | 981350 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A chlorinated methyl jasmonate analog (J7) was elaborated as an in vitro anti-inflammatory lead. However, its in vitro efficacy profile was not reproduced in a subsequent in vivo evaluation, presumably due to its rapid enzymatic hydrolysis in a biological system. In an attempt to improve the metabolic stability of the lead J7 by replacement of its labile methyl ester with reasonable ester groups, several analogs resistant to enzymatic hydrolysis were synthesized. In vivo evaluation of the stability-improved analogs showed that these compounds displayed higher efficacy than the lead J7, suggesting that these new jasmonate analogs may serve as potential anti-inflammatory leads.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 13, 1 July 2012, Pages 4109–4116
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 13, 1 July 2012, Pages 4109–4116
نویسندگان
Hung The Dang, Yoon Mi Lee, Gyeoung Jin Kang, Eun Sook Yoo, Jongki Hong, Sun Mee Lee, Sang Kook Lee, Yuna Pyee, Hwa-Jin Chung, Hyung Ryong Moon, Hyung Sik Kim, Jee H. Jung,