Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation

As part of ongoing studies in developing new antimicrobials, we report the synthesis of a new class of structurally novel derivatives, that incorporate two known bioactive structures a thiazole and chalcone, to yield a class of compounds with interesting antimicrobial properties.Evaluation of antibacterial activity showed that almost all the compounds exhibited greater activity than reference drugs and thus could be promising novel drug candidates.

A new class of structurally novel thiazole based chalcones were synthesized and evaluated for their antimicrobial and antifungal activity.Figure optionsDownload as PowerPoint slide