Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation

A series of rabdokunmin C analogues were prepared and their inhibitory effect on NF-κB activation was assayed. One of them, 18-acetyl-12-deoxy-11,12-dehydrorabdokunmin C (16) was found to be a promising candidate for an anti-inflammatory agent.

Synthesis of rabdokunmin C analogues was carried out. SAR study of their analogues on inhibitory activity of NF-κB activation was also reported.Figure optionsDownload as PowerPoint slide