کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1358978 981374 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microbial transformation of (+)-nootkatone and the antiproliferative activity of its metabolites
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Microbial transformation of (+)-nootkatone and the antiproliferative activity of its metabolites
چکیده انگلیسی

Six metabolites were obtained as a result of microbial transformation of (+)-nootkatone (1) by the fungal strains: Botrytis, Didymosphaeria, Aspergillus, Chaetomium and Fusarium. Their structure were established as (+)-(4R,5S,7R,9R)-9α-hydroxynootkatone (2), (+)-(4R,5S,7R)-13-hydroxynootkatone (3) and (+)-(4R,5S,7R,9R,11S)-11,12-epoxy-9α-hydroxynootkatone (4), (+)-(4R,5S,7R,11S)-11,12-epoksynootkatone (5), (+)-(4R,5S,7R)-11,12-dihydroxynootkatone (6) and (+)-(4R,5S,7R)-7,11,12-trihydroxynootkatone (7) on the basis of their spectral data. Two products: (4) and (7) were not previously reported in the literature. The antiproliferative activity of (+)-nootkatone (1) and isolated metabolites (2–7) of its biotransformation has been evaluated.

We report the microbial transformation of natural bicyclic ketone–(+)-nootkatone (1). We proposed the metabolic pathway of (+)-nootkatone in fungal culture studied and showed the antiproliferative activity of obtained metabolites towards cancer cell lines A549 (human lung adenocarcinoma) and HL-60 (human promyelocytic leukemia).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 7, 1 April 2011, Pages 2464–2469
نویسندگان
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