کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1358989 | 981375 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of [11C]metergoline as a PET radiotracer for 5HTR in nonhuman primates
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of [11C]metergoline as a PET radiotracer for 5HTR in nonhuman primates Evaluation of [11C]metergoline as a PET radiotracer for 5HTR in nonhuman primates](/preview/png/1358989.png)
چکیده انگلیسی
Metergoline, a serotonin receptor antagonist, was labeled with carbon-11 in order to evaluate its pharmacokinetics and distribution in non-human primates using positron emission tomography. [11C]Metergoline had moderate brain uptake and exhibited heterogeneous specific binding, which was blocked by pretreatment with metergoline and altanserin throughout the cortex. Non-specific binding and insensitivity to changes in synaptic serotonin limit its potential as a PET radiotracer. However, the characterization of [11C]metergoline pharmacokinetics and binding in the brain and peripheral organs using PET improves our understanding of metergoline drug pharmacology.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 22, 15 November 2010, Pages 7739–7745
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 22, 15 November 2010, Pages 7739–7745
نویسندگان
Jacob M. Hooker, Sung Won Kim, Achim T. Reibel, David Alexoff, Youwen Xu, Colleen Shea,