کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359006 981375 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity
چکیده انگلیسی

A significant acetylcholinesterase (AChE) inhibitory activity was observed for the hexane extract from the bark of Mesua elegans (Clusiaceae). Thus, the hexane extract was subjected to chemical investigation, which led to the isolation of nine 4-phenylcoumarins, in which three are new; mesuagenin A (1), mesuagenin C (3), mesuagenin D (4) and one new natural product; mesuagenin B (2). The structures of the isolated compounds were characterized by spectroscopic data interpretation, especially 1D and 2D NMR. Four compounds showed significant AChE inhibitory activity, with mesuagenin B (2) being the most potent (IC50 = 0.7 μM).

Nine 4-phenylcoumarins have been isolated from Mesua elegans, in which three are new; mesuagenin A, mesuagenin C, mesuagenin D, and one is a newly reported natural product; mesuagenin B. Chemical structures were elucidated using spectroscopic techniques, notably 1D and 2D NMR spectroscopy. Four compounds showed significant inhibitory activity against acetylcholinesterase, with mesuagenin B being the most potent (IC50 = 0.7 μM).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 22, 15 November 2010, Pages 7873–7877
نویسندگان
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