کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359270 981398 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Insulinomimetic activity of two new gallotannins from the fruits of Capparis moonii
چکیده انگلیسی

Bioassay guided fractionation of the hydro-alcoholic extract of the fruits of Capparis moonii, led to the isolation of two new chebulinic acid derivatives. The compounds 1 and 2 displayed significant glucose uptake effect of 223% and 219% over the control at the 10 ng/ml and 100 ng/ml concentration, respectively. The increased glucose uptake effects of the compounds were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.

Bioassay guided fractionation of the hydro-alcoholic extract of Capparis moonii fruit, led to the isolation of two new Chebulinic acid derivatives. The compounds, 1 and 2 showed significant glucose uptake effect of 223% and 219% over the control at the 10 ng/ml and 100 ng/ml concentration, respectively. The increased glucose uptake effects of the compounds, were associated with significant IR and IRS-1 phosphorylation, GLUT4 and PI3-kinase mRNA expression in the L6 cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 11, 1 June 2010, Pages 3940–3945
نویسندگان
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