کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359409 | 981402 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9–4.5 μM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G2/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.
The preparation of tessaric acid derivatives and their antitumor properties are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 17, 1 September 2009, Pages 6251–6256
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 17, 1 September 2009, Pages 6251–6256
نویسندگان
Leticia G. León, Osvaldo J. Donadel, Carlos E. Tonn, José M. Padrón,