کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359468 981403 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines
چکیده انگلیسی

The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on kcat and have been separated in weak (KA in the range of 21–126 μM), medium (10.1–19 μM) and strong enzyme activators (KA of 0.18–3.21 μM). D-DOPA was found to be the best coral enzyme activator, with an activation constant KA of 0.18 μM. This enhancement of STPCA activity, as well as previous enzyme inhibition results, might now be tested on living organisms to better understand the role played by these enzymes in the coral calcification processes.

Stylophora pystillata (coral) CA is activated by amines and amino acids.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 6, 15 March 2010, Pages 2300–2303
نویسندگان
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