Novel 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents

Sixteen novel compounds; 3α-methoxyserrat-14-en-21β-ol (1) and 3β-methoxyserrat-14-en-21β-ol (2) and their curcumin, kojic acid, quercetin, and baicalein conjugates (3)–(18) were designed, synthesized, and evaluated for in vitro anti-HIV-1 reverse transcriptase (RT) activity in infected C8166-CCR5 cells, a human CD4+ T-lymphocyte cell line. Among them, kojic acid derivatives, 9–12 showed significant biological activity. In particular, the compound 13, the conjugate of two molecules of 3α-methoxyserrat-14-en-21β-ol (1) and one molecule of kojic acid, exerted significant anti-HIV activity with an EC50 value of 0.12 μg/mL.

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