کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359614 | 981407 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel l-adenosine analogs as cardioprotective agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Two l-nucleosides, l-3â²-amino-3â²-deoxy-N6-dimethyladenosine (l-3â²-ADMdA) 1, previously synthesized in our laboratory, and the novel l-3â²-amino-3â²-deoxy-N6-methyladenosine-5â²-N-methyluronamide (l-3â²-AM-MECA) 2 were evaluated in an ischemia/reperfusion model on Langendorff perfused mouse heart. l-3â²-ADMdA 1 was found to enhance functional recovery from ischemia (32.2 ± 3.7 cm H2O/s % rate pressure product, compared to 21.3 ± 1.4 for the control and 30.7 ± 3.4 for adenosine) and increase the time to onset of ischemic contracture (14.5 ± 0.9 min, compared to 10.5 ± 1.0 min for the control and 13.6 ± 0.6 min for adenosine) comparable to adenosine. Consistent with the functional recovery data, decreased infarction area was seen in the case of 1 (19.1 ± 8.4, compared to 40.5 ± 7.2% for the control and 11.5 ± 2.1% for adenosine). In contrast, l-3â²-AM-MECA 2 did not show significant functional recovery, increased onset of contracture, nor decreased infarction area compared to control. Unlike adenosine, neither 1 nor 2 induced cardiac standstill in mouse heart.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 14, 15 July 2009, Pages 5347-5352
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 14, 15 July 2009, Pages 5347-5352
نویسندگان
Harinath Kasiganesan, Gary L. Wright, Maria Assunta Chiacchio, Giuseppe Gumina,