کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359646 981408 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Isolation, structure, and bioactivities of abiesadines A–Y, 25 new diterpenes from Abies georgei Orr
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Isolation, structure, and bioactivities of abiesadines A–Y, 25 new diterpenes from Abies georgei Orr
چکیده انگلیسی

Twenty-five new (abiesadines A–Y, 1–25) and 29 known (26–54) diterpenes were isolated from the aerial parts of Abies georgei. Abiesadine A (1) is a novel 8,14-seco-abietane, while abiesadine B (2) is a novel 9,10-seco-abietane. The structures of the new compounds were established on the basis of spectroscopic data analysis. Manool (52) showed the strongest effect against LPS-induced NO production in RAW264.7 macrophages with the IC50 value of 11.0 μg/mL. In another anti-inflammatory assay against TNFα-triggered NF-κB activity, (12R,13R)-8,12-epoxy-14-labden-13-ol (54) exhibited the strongest effect (IC50 = 8.7 μg/mL). For antitumor assays, pomiferin A (26) and 8,11,13-abietatriene-7α,18-diol (29) both showed the most significant activity against LOVO cells (IC50 = 9.2 μg/mL). While 7-oxocallitrisic acid (46) exhibited significant cytotoxicity against QGY-7703 tumor cells (IC50 = 10.2 μg/mL).

Twenty-five new diterpenes, abiesadines A–Y (1–25) were isolated from the aerial parts of Abies georgei together with 29 known ones (26–54).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 2, 15 January 2010, Pages 744–754
نویسندگان
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