Diether derivatives of homo- or substituted piperidines as non-imidazole histamine H3 receptor ligands

New diethers 4-16 were prepared and evaluated for their in vitro binding affinities at human histamine H3 receptor. The 3-methylpiperidine derivative 11 (R1 = 3-CH3, m = 1, n = 3, R2 = 4-Cl) is the most potent compound (Ki value of 3.2 nM) in this series.