کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1359782 | 981413 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
Several (2-oxaadamant-1-yl)amines have been synthesized and their antiviral, NMDA receptor antagonist, and trypanocidal activities have been studied.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 8, 15 April 2009, Pages 3198–3206
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 8, 15 April 2009, Pages 3198–3206
نویسندگان
María D. Duque, Pelayo Camps, Lenuta Profire, Silvia Montaner, Santiago Vázquez, Francesc X. Sureda, Jordi Mallol, Marta López-Querol, Lieve Naesens, Erik De Clercq, S. Radhika Prathalingam, John M. Kelly,