Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.

Several (2-oxaadamant-1-yl)amines have been synthesized and their antiviral, NMDA receptor antagonist, and trypanocidal activities have been studied.Figure optionsDownload as PowerPoint slide