کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1359796 981415 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II
چکیده انگلیسی

Calcium/calmodulin dependent protein kinase II (CaMKII) is involved in the mechanisms underlying higher order brain functions such as learning and memory. CaMKII participates in pathological glutamate signaling also, since it is activated by calcium influx through the N-methyl-d-aspartate type glutamate receptor (NMDAR). In our attempt to identify phytomodulators of CaMKII, we observed that curcumin, a constituent of turmeric and its analogs inhibit the Ca2+-dependent and independent kinase activities of CaMKII. We further report that a heterocyclic analog of curcumin I, (3,5-bis[β-(4-hydroxy-3-methoxyphenyl)ethenyl]pyrazole), named as pyrazole-curcumin, is a more potent inhibitor of CaMKII than curcumin. Microwave assisted, rapid synthesis of curcumin I and its heterocyclic analogues is also reported.

The inhibition of CaMKII kinase activity by natural curcumin I (1) and its two pyrazole derivatives (4, 5) and one isoxazole derivative (6) is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 20, 15 October 2012, Pages 6040–6047
نویسندگان
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