Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides.

Anti-HIV fusion inhibitory peptides with N- and C-terminal end-capping groups was synthesized by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins.Figure optionsDownload as PowerPoint slide