Antibacterial activity of aminoderivatized chitosans against methicillin-resistant Staphylococcus aureus (MRSA)

This work describes the anti-MRSA activity of aminoderivatized chitosans. Two kinds of aminoethyl-chitosans (AEC), AEC90 and AEC50, having degrees of deacetylation of 90% and 50%, respectively, exhibited the strongest anti-MRSA activities by presenting MICs of 16–64 μg/mL against two standard strains and twelve clinical isolates. The bactericidal activity, thermal and pH stability, and cell membrane integrity effects of AEC90 and AEC50 are also discussed.

Two kinds of aminoethyl-chtiosans (AEC), AEC90 and AEC50, having degrees of deacetylation of 90% and 50%, exhibited the strongest anti-MRSA activities by presenting MICs of 16–64 μg/mL against two standard strains and twelve clinical isolates.Figure optionsDownload as PowerPoint slide