Interaction of genistein benzyl derivatives with lipid bilayers—fluorescence spectroscopic and calorimetric study

The purpose of the present paper was to assess the ability of genistein benzyl derivatives to interact with lipid bilayers. Calorimetric and fluorescence spectroscopic measurements revealed that, depending on the details of chemical structure, the studied compounds penetrated bilayers and affected their polar as well as hydrophobic regions. It was also found that physical state of bilayer played some role in flavonoid–lipid interactions.

Newly synthesized genistein benzyl derivatives perturb polar and hydrophobic region of lipid bilayer. Their interaction with membrane depends on its physical state.Figure optionsDownload as PowerPoint slide