کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1360097 | 981424 | 2010 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents](/preview/png/1360097.png)
The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H2O2-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-κB, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H2O2, was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases.
A novel series of 1,2,4-triazine derivatives were synthesized and evaluated for their neuroprotective effect.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 12, 15 June 2010, Pages 4224–4230