Synthesis and biological evaluation of 2,3,4-triarylbenzopyran derivatives as SERM and therapeutic agent for breast cancer

A library of novel 2,3,4-triarylbenzopyrans was synthesized and their SERM and anti-proliferative activities were evaluated. Compound 12a showed the lowest IC50 at 7 μM against MCF-7 and 11f showed the lowest IC50 value of 5.6 μM against MDA-MB-231 cell lines.