Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives

A convenient route for the synthesis of some 2-propen-1-one derivatives with E isomeric configuration is described. The activity of the synthesized compounds was evaluated through behavioral studies of apomorphine-induced licking in animal models. It was demonstrated that most of the synthesized compounds showed moderate activity in inhibition of lickings, among which 6a, was the most active compound at 30 mg/kg.

A series of E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives have been synthesized and evaluated for dopaminergic activity in animal models.Figure optionsDownload as PowerPoint slide