Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2

This work describes the synthesis and anti-inflammatory properties of a pentadienone derivative, HB2. The treatment with HB2 produced anti-oedematogenic, anti-inflammatory and antinociception without change locomotors performance. Finally, HB2 reduced the nitric oxide and prostaglandin E2 production on RAW 264.7 cells stimulated with LPS without changing the cell viability. Taken together, our results show, for the first time, that HB2 can modulate the inflammatory response when administered to mice.

We have a patent to general procedure used for synthesis of pentadienones: with potent antitumoral effect. In this work we have investigate the anti-inflammatory effect of HB2.The chemical structure and characterization of HB2 can be found here. This compound is denominated 1,5-bis(4-acetoxy-3-methoxyphenyl)-penta-1,4-dien-3-one (Pat. No PI 0207141-0, 28.11.2002; PCT/BR 2003/000177).Figure optionsDownload as PowerPoint slide