In vitro and in vivo studies of 6,8-(diaryl)imidazo[1,2-a]pyrazin-3(7H)-ones as new antioxidants

A series of novel 3,5-diaryl-2-amino-1,4-pyrazine derivatives and related imidazo[1,2-a]pyrazin-3(7H)-ones has been synthesized to study the in vitro chemical oxidative degradation pathways of the hetero-bicycles. The antioxidant potential of those compounds has been evaluated in vivo.