QSAR study on maximal inhibition (Imax) of quaternary ammonium antagonists for S-(−)-nicotine-evoked dopamine release from dopaminergic nerve terminals in rat striatum

A QSAR study on a set of mono- and bis-quaternary ammonium salts that act as antagonists at neuronal nicotinic acetylcholine receptors mediating nicotine-evoked dopamine release was conducted using multi-linear regression and neural network analysis. The maximal inhibition (Imax) values of the compounds exhibited a good correlation with the predictions made by the QSAR models developed.