کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1360284 | 981432 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on FcεRI expression Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on FcεRI expression](/preview/png/1360284.png)
Two bioactive phloroglucinol derivatives, dioxinodehydroeckol (DHE) and phlorofucofuroeckol A (PFF-A) were isolated from edible marine brown alga, Ecklonia stolonifera, and evaluated for effects on cell surface FcεRI expression in KU812F cells. DHE and PFF-A were found to reduce the cell surface expression, and total cellular protein and mRNA levels for the FcεRI α chain. Moreover, both compounds exerted inhibitory effects against the elevation of intracellular calcium concentration [Ca2+]i and histamine release from anti-FcεRI α chain antibody (CRA-1)-stimulated cells. These inhibitory effects were stronger for PFF-A than for DHE. These results show that two phloroglucinol derivatives, DHE and PFF-A, may exert anti-allergic effects via the inhibition of FcεRI expression, calcium influx, and degranulation in basophils, and contributes to the pharmacological activities of marine brown alga, including E. stolonifera.
Down-regulation of FcεRI expression by dioxinodehydroeckol (DHE) and phlorofucofuroeckol A (PFF-A) isolated from E. stolonifera induces inhibition of FcεRI-mediated calcium influx and histamine release.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 13, 1 July 2009, Pages 4734–4739