کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1360294 | 981432 | 2009 | 6 صفحه PDF | دانلود رایگان |

A 5′-terminal 2,2,7-trimethylguanosine (TMG) cap structure plays an important role in transport of TMG-capped snRNAs from the cytoplasm to the nucleus in living cells. This property can be expected to be used for carrying artificial nucleic acids into the nucleus in gene therapy. In this paper, a new TMG-capping reagent 1 was developed and used for the synthesis of oligodeoxynucleotides having a 5′-terminal TMG-capped pyrophosphate linkage (m32,2,7G5′pp-DNA) lacking one phosphate group using a silyl-type linker on polymer supports.
A new TMG-capping reagent 1 was developed and used for the synthesis of oligodeoxynucleotides having a 5′-terminal TMG-capped pyrophosphate linkage (m32,2,7G5′pp-DNA) lacking one phosphate group by using a silyl-type linker on polymer supports.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry - Volume 17, Issue 13, 1 July 2009, Pages 4819–4824